Installation

System Requirements

• Operating System: Windows XP/Vista/7
• Memory Requirements: Minimum of 4 GB

Installation

After downloading and unzipping TARGETgene.zip, you will find two executable files (TARGETgene.exe and MCRInstaller.exe) and the following sub-directories under the directory TARGETgene.

• Genetic-Interactions
  This includes 42 files containing the genetic interactions named as yrvm_exp_1~42.mat.
• Annotations
  This contains data files for annotating your predicted results, including literature citation, gene, and drug information.
• Examples
  This contains two sub-directories, EX1 and EX2. “EX1” contained files for example 1, including three lists of differentially expressed genes of three cancer types (BreastCancer_Genes.txt; ColonCancer_Genes.txt; LungCancer_Genes.txt), three lists of genes detected by cell viability RNAi screens (Breast_siRNA.txt; Colon_siRNA.txt; Lung_siRNA.txt). “EX2” contained files for example 2, including a list of mutated genes (Altered_Genes.txt), a list of all genes in the genome (AllGenes.txt), a list of genes in the core pathways of GBM (Genes_CorePathways.txt).

To run TARGETgene, it is first necessary to install the latest MATLAB Runtime Libraries (MCRInstaller.exe) if you do not have MATLAB already installed on your computer. Double-click the installer “MCRInstaller.exe”. The Installer will create the appropriate directory structure and modify the system path. Reboot your computer after installation.

Execute TARGETgene

After installing the MATLAB Runtime Libraries if needed, double-click the file “TARGETgene.exe”.