System Requirements

  • Operating System: Windows XP/Vista/7
  • Memory Requirements: Minimum of 4 GB


After downloading and unzipping, you will find two executable files (TARGETgene.exe and MCRInstaller.exe) and the following sub-directories under the directory TARGETgene.

  • Genetic-Interactions
    This includes 42 files containing the genetic interactions named as yrvm_exp_1~42.mat.
  • Annotations
    This contains data files for annotating your predicted results, including literature citation, gene, and drug information.
  • Examples
    This contains two sub-directories, EX1 and EX2. “EX1” contained files for example 1, including three lists of differentially expressed genes of three cancer types (BreastCancer_Genes.txt; ColonCancer_Genes.txt; LungCancer_Genes.txt), three lists of genes detected by cell viability RNAi screens (Breast_siRNA.txt; Colon_siRNA.txt; Lung_siRNA.txt). “EX2” contained files for example 2, including a list of mutated genes (Altered_Genes.txt), a list of all genes in the genome (AllGenes.txt), a list of genes in the core pathways of GBM (Genes_CorePathways.txt).

To run TARGETgene, it is first necessary to install the latest MATLAB Runtime Libraries (MCRInstaller.exe) if you do not have MATLAB already installed on your computer. Double-click the installer “MCRInstaller.exe”. The Installer will create the appropriate directory structure and modify the system path. Reboot your computer after installation.

Execute TARGETgene

After installing the MATLAB Runtime Libraries if needed, double-click the file “TARGETgene.exe”.

Latest Posts About TARGETgene

  • TARGETgene 2.0beta
    A fusion gene that results from chromosome rearrangements is a hybrid gene formed from distinct genes, either in the same chromosome or in different chromosomes. Many recurring gene fusions, such as BCR-ABL in chronic myelogenous leukemia, EWS-FIL1 in Ewing’s Sarcoma, and TMPRSS2-ERG in prostate cancer, play important roles in cancer progression. As such, they have…Continue Reading TARGETgene 2.0beta
  • Release of TARGETgene
    The vast array of in silico resources currently available in the life sciences research offers the possibility of aiding the drug discovery process. Core Project 1 of the BMSR has developed TARGETgene to exploit these resources and to allow the identification of potential therapeutic targets and drugs in cancer using genetic network-based approaches. TARGETgene is…Continue Reading Release of TARGETgene