The emphasis of the Core Research projects is on the development of advanced modeling and simulation methodologies and their application to physiological systems for the advancement of scientific knowledge and improvement of clinical practice. The challenging cases of nonlinear, nonstationary, sparse data and feedback systems, as well as the issues of physiological control, neural information processing, learning and memory, pharmacokinetics and pharmacodynamics, and modeling/simulation of complex biomedical systems constitute the focal points of this effort. The methodologies explored and developed by the Core projects are at the cutting edge of research in each area. Together they comprise a research ensemble of common origin and coherent scope, yet pluralistic in methodological approach and application focus. Pivotal applications of these methodologies cover a variety of physiological domains, including pharmacokinetics, respiratory, cardiovascular, neural, sensory and motor systems.

Core Investigators

Core Project #1
Pharmacokinetic/Pharmacodynamic Systems Modeling & Analysis

David Z. D’Argenio, Ph.D.
Professor, Biomedical Engineering
Chonette Chair in Biomedical Technology

Core Project #2
Biomedical Systems Modeling for Improved Clinical Diagnosis & Treatment

Vasilis Z. Marmarelis, Ph.D.
Professor, Biomedical Engineering

Core Project #3
Models of Multi-Factor Disorders in Cardiorespiratory Control


Michael C.K. Khoo, Ph.D.
Professor, Biomedical Engineering

Core Project #4
Multi-Scale Modeling of Hippocampal Dynamics and Neural Prostheses

Theodore W. Berger, Ph.D.
Professor, Biomedical Engineering and Neurobiology
David Packard Chair of Engineering