EONS v1 is the perfect tool to study the basic interactions between synaptic elements in a friendly manner. There are no complicated equations to write: all the models are predefined! This version is a great tool for first time users and students interested in learning about synapses, as well as for studying geometry and distribution hypotheses in a 2D rectangular geometry.

From a computational standpoint, EONS is currently a windows only application.

See EONS v1 in action: visual feedback during a EONS v1 simulation with an initial presynaptic paired-pulse depolarization – Calcium enters in the presynaptic terminal and triggers glutamate release.

Structure of EONS v1.*

EONS consists in a graphical modeling platform in which elements that comprise a single glutamatergic synapse (both pre- and post-synaptically) as well as the underlying synaptic geometry can be modified.

This animation describes the main mechanisms involved during glutamatergic synaptic tranmission occuring after initial presynaptic depolarization.

Presynaptic elements

  • Calcium channels (N, L, T types)
  • Localized calcium buffers
  • Diffuse calcium buffers
  • Calcium diffusion modeling
  • Calcium pumps
  • vesicular kinetics

Synaptic cleft

In the synaptic cleft, a uniform diffusion of neurotransmitter is modeled (we focus our attention to the area close the the release site).

Postsynaptic elements

  • AMPA receptors
  • NMDA receptors
  • Metabotropic glutamate receptors
  • Endoplasmic Reticulum (ER)
  • ER calcium ATPase
  • ER IP3 receptors
  • Simulated excitatory postsynaptic potential

We are currently in the process of adding several elements to the postsynaptic density:

  • Slow and medium potassium channels
  • Calcium channels
  • Sodium/calcium exchanger
  • Long Term Potentiation (LTP)

For more information, consult the user guide.

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