The high-level capabilities of TARGETgene are demonstrated through two examples. The two examples are illustrative of the capabilities and use of TARGETgene in identifying potential therapeutic targets from thousands of differentially expressed genes (Example 1) and driver genes (Example 2) in cancer. The complete details for the two examples, as well as background information on the constructed gene network used by TARGETgene are provided in the Supplemental Material below. Two PowerPoint files that illustrate the usage of TARGETgene in the two examples are also provided below.
Supplemental Material (PDF)
Examples (PDF)
Latest Posts About TARGETgene
- TARGETgene 2.0betaA fusion gene that results from chromosome rearrangements is a hybrid gene formed from distinct genes, either in the same chromosome or in different chromosomes. Many recurring gene fusions, such as BCR-ABL in chronic myelogenous leukemia, EWS-FIL1 in Ewing’s Sarcoma, and TMPRSS2-ERG in prostate cancer, play important roles in cancer progression. As such, they have…Continue Reading TARGETgene 2.0beta
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