A fusion gene that results from chromosome rearrangements is a hybrid gene formed from distinct genes, either in the same chromosome or in different chromosomes. Many recurring gene fusions, such as BCR-ABL in chronic myelogenous leukemia, EWS-FIL1 in Ewing’s Sarcoma, and TMPRSS2-ERG in prostate cancer, play important roles in cancer progression. As such, they have…Continue Reading TARGETgene 2.0beta
Category: TARGETgene
Release of TARGETgene
The vast array of in silico resources currently available in the life sciences research offers the possibility of aiding the drug discovery process. Core Project 1 of the BMSR has developed TARGETgene to exploit these resources and to allow the identification of potential therapeutic targets and drugs in cancer using genetic network-based approaches. TARGETgene is…Continue Reading Release of TARGETgene