Archive for October, 2018

Support for Intel Parallel Studio XE 2019 Fortran Compiler

ADAPT (version 5.0.059). The installation was updated to include the Intel Parallel Studio XE 2019 Fortran Compiler. See Installation Tab file on the ADAPT download page of the BMSR web site for full details.

Feedback Control Indirect Response Models

A recent publication in the Journal of PK/PD presents a general framework for modeling pharmacodynamic processes that are subject to autoregulation. Yaping Zhang and David Z. D’Argenio. Feedback control indirect response models. Journal of Pharmacokinetics and Pharmacodynamics.43(4) :343-358, 2016. DOI: 10.1007/s10928-016-9479-8 A general framework is introduced for modeling pharmacodynamic processes that are subject to autoregulation, which combines the indirect response (IDR) model approach with methods from classical feedback control of engineered systems. The canonical IDR models are modified to incorporate linear combinations of feedback control terms related to the time course of the difference (the error signal) between the pharmacodynamic response and its basal value. Following the well-established approach of traditional engineering control theory, the proposed feedback control indirect response models incorporate terms proportional to the error signal itself, the integral of the error signal, the derivative of the error signal or combinations thereof. Simulations are presented to illustrate the… Read more