RAD-ADAPT is a comprehensive software solution for the quantitative analysis of clonogenic assays in radiation biology. Two commonly used models for clonogenic assay analysis are implemented in the software: the linear-quadratic model and the single-hit multi-target model. RAD-ADAPT uses maximum likelihood estimation to obtain parameter estimates with the assumption that cell colony count data follow a Poisson distribution. The software has an intuitive interface, generates model prediction plots, tabulates model parameter estimates, and allows automatic statistical comparison of parameters between different groups.
It has been created by Dr. Yaping Zhang and Prof. David Z. D’Argenio, in conjunction with Drs. Jan H. Beumer and Christopher J. Bakkenist at the University of Pittsburgh, within the BMSR Collaborative Research Project framework.
System Requirements
- Operating System: Windows 7/8/10
- Other Software Required: R
RAD-ADAPT has been developed by the Biomedical Simulations Resource at the University of Southern California, under support from the National Institute for Biomedical Imaging and Bioengineering (NIBIB) at the National Institutes of Health (P41-EB001978). It is distributed by the BMSR at no charge to the user, under the terms of a Release Agreement.
Our ability to further develop and support RAD-ADAPT depends on the degree to which it is used by the research community. Accordingly, we ask that you acknowledge any use of RAD-ADAPT in your research publications, by citing the reference below. Also, please direct any questions to Dr. Yaping Zhang at: ask.yaping@gmail.com .
Y. Zhang, K. Hu, J. H. Beumer, C. J. Bakkenist and D. Z. D’Argenio, RAD-ADAPT:
software for modelling clonogenic assay data in radiation biology. DNA Repair. 52:24-30, 2017. PubMed: 28254357, DOI: 10.1016/j.dnarep.2017.02.004