Modeling Intracellular Signaling in Cancer
A recent publication in the Journal of PK/PD presents a model-based analysis of the effects of anti-cancer drugs that act on the apoptotic pathway of ...Read more
A recent publication in the Journal of PK/PD presents a model-based analysis of the effects of anti-cancer drugs that act on the apoptotic pathway of ...Read more
Recent results of model-based "functional biomarkers" were presented in the IEEE Conference on Engineering in Medicine & Biology (San Diego, August 2012) that demonstrate the ...Read more
An extensive overview of the efforts that have been made to better understand the pathophysiology of metabolic syndrome using computational modeling will be published in ...Read more
A recent publication in the IEEE Transactions on Neural Systems and Rehabilitation Engineering presents the application and hardware fabrication of the multi-input, multi-output (MIMO) nonlinear ...Read more
Pharmacokinetic / Pharmacodynamic Systems Analysis
David Z. D’Argenio, Ph.D.
Co-Director
Nonlinear Modeling of Complex Biomedical Systems
Vasilis Z. Marmarelis, Ph.D.
Co-Director
Modeling of Autonomic, Metabolic and Vascular Control Interactions
Michael C.K. Khoo, Ph.D.
Co-Investigator
Four Core Research projects develop advanced biomedical systems modeling and simulation methodologies and tools focusing on the challenging cases of nonlinear, nonstationary, sparse data and feedback systems.
Collaborative Research projects serve as challenging test beds for the Resource’s methodologies and expertise in a range of biomedical domains including: neural, sensory, respiratory, cardiovascular systems, as well as pharmacokinetic/pharmacodynamic processes.
The BMSR’s Service activities include the distribution and user support of our software tools ADAPT, EONS, LYSIS, PNEUMA & TARGETgene.
The Resource’s Training and Dissemination activities include software and methodology short courses, workshops and sponsorships of meetings and symposia.
The BMSR is support through grant P41-EB001978 from the National Institute of Biomedical Imaging and Bioengineering of the NIH and has been continuously funded as an NIH Research Resource since 1985.