Modeling Intracellular Signaling in Cancer
A recent publication in the Journal of PK/PD presents a model-based analysis of the effects of anti-cancer drugs that act on the apoptotic pathway of ...Read more
A recent publication in the Journal of PK/PD presents a model-based analysis of the effects of anti-cancer drugs that act on the apoptotic pathway of ...Read more
Recent results of model-based "functional biomarkers" were presented in the IEEE Conference on Engineering in Medicine & Biology (San Diego, August 2012) that demonstrate the ...Read more
An extensive overview of the efforts that have been made to better understand the pathophysiology of metabolic syndrome using computational modeling will be published in ...Read more
A recent publication in the IEEE Transactions on Neural Systems and Rehabilitation Engineering presents the application and hardware fabrication of the multi-input, multi-output (MIMO) nonlinear ...Read more
Pharmacokinetic / Pharmacodynamic Modeling & Systems Analysis
David Z. D’Argenio, Ph.D.
Co-Director
Biomedical Systems Modeling for Improved Clinical Diagnosis & Treatment
Vasilis Z. Marmarelis, Ph.D.
Co-Director
Models of Multi-Factor Disorders in Cardiorespiratory Control
Michael C.K. Khoo, Ph.D.
Co-Investigator
Multi-Scale Modeling of Hippocampal Dynamics and Neural Prostheses
Theodore W. Berger, Ph.D.
Co-Investigator
Four Core Research projects develop advanced biomedical systems modeling and simulation methodologies and tools focusing on the challenging cases of nonlinear, nonstationary, sparse data and feedback systems.
Collaborative Research projects serve as challenging test beds for the Resource’s methodologies and expertise and address challenging translational and clinical problems: cardiovascular/respiratory & metabolic diseases; neurovascular & neurodegenerative diseases; neurostimulation & functional neurosurgery; and oncology & infectious diseases.
The BMSR’s Service activities include the distribution and user support of our software tools ADAPT, EONS, LYSIS, PNEUMA & TARGETgene.
The Resource’s Training and Dissemination activities include software and methodology short courses, workshops and sponsorships of meetings and symposia.
The BMSR is support through grant P41-EB001978 from the National Institute of Biomedical Imaging and Bioengineering of the NIH and has been continuously funded as an NIH Research Resource since 1985.