All posts from EONS

New Version of EONS v1.2

New Version of EONS v1.2. Significant speed improvements, batch simulations, etc… (see history for release notes) (Windows version only )

EONS V1.1.3 Release 362

Bugs Fixes: None. Models modifications: Internals: All models are generated using SBML and incorporated in EONS New numerical methods significantly decrease computation time (Heun-Euler, RKF and BDF2TRAP variable step methods) Simplified presynaptic calcium diffusion available Neurotransmitter diffusion based on Savtchenko paper (faster than 2D convolution) Code cleanup: A lot of cleanup in the main interface classes. Enhancements: Significant reduction in memory usage Significant speed improvement Anti-aliasing used by default (after detection of the client OS and the determination of the appropriate font to use) One can now save the results in Matlab format Interface cleaned up a bit

New Version of EONS v1.1.3

New Version of EONS < a href="http://128.125.37.80:8080/login.html">v1.1.3. Significant speed improvements, GABA feed-forward, etc… (see history for release notes)

New Version of EONS v1.1.2

New Version of EONS v1.1.2. New AMPA and NMDA receptors. 2 subversions exist: a ‘student’ and ‘normal’ version (see history for release notes)

EONS V1.1.2 Release 141

Bugs Fixes: Issues on Linux and Mac clients should be fixed. Models modifications: A LOT OF Internal modifications: we are heading towards full compatibility with SBML. i.e. in a near future, you will be able to develop your own elementary model (NMDA receptor, calcium channels, etc…) and incorporate it in EONS New VDCCs implement a variable step method (significant gain in computation time) Optimized parameters of presynaptic calcium diffusion Spine neck resistance added in postsynaptic depolarization calculation Code cleanup: Some cleanup in the main interface classes. Enhancements: Significant reduction in memory usage Significant speed improvement Anti-aliasing used by default (after detection of the client OS and the determination of the appropriate font to use) One can now save the results in Matlab format

EONS V1.1 Release 99

Bugs Fixes: none. Models modifications: new AMPA and NMDA receptors. Code cleanup: Diffusion of neurotransmitter in the cleft optimized Enhancements: AMPA and NMDA receptors implement a variable step method (significant gain in computation time)

EONS V1.0 Release 88

Bugs Fixes: none. Models modifications: Glycine transporter GlyT1 recalibrated. Code cleanup: Metabotropic receptor type 1 has its own location and icon. Enhancements: Added 13 states model for AMPA receptor.

EONS V1.0 Release 49

Bugs Fixes: none. Models modifications: new layout of presynaptic VDCCs. Code cleanup: none. Enhancements: Added glycine transporter GlyT1 on glial cell adjacent to the synapse that controls the amount og glycine present. Added histamine receptor H3 that controls the level of inhibition of VDCCs.

EONS V1.0 Release 40

Bugs Fixes: logo in about window not present (ImageIcon exception); proper initialization of AMPA5 receptors. Models modifications: NT release uses model from Yamada and Zucker 1992; new synapse layout to reproduce the Yamada and Zucker 1992 [Ca]pre profile (No vdcc T type, more L type); presynaptic ca buffer modified to fit Yamada and Zucker 1992 [Ca]pre profile; NMDA has 3 conductances (Ca, Na and K). Code cleanup: Load defaults from each model panel rather than main frame. Enhancements: Output graphs are generated in a smart way (points with no information are removed (precision = range/400)); Graph-> View dataset generates only an output for the selected graph; Graph-> View dataset. The X axis in the table is now in ms (and formatted); calcium buffer has now a clearing rate accessible from the user interface.

EONS V1.0

Note: Improved user interface. Ability to close results panel to free memory space. Feedback when the system is running low in memory space.

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