2-compartment IV with subject creatinine clearance and weight as covariates that change over the dose regimen. Contributed by Alan Forrest.

2-compartment IV with Michaelis-Menten elimination. Enzyme induction modeled as increase in Vmax with time after start of dose. Contributed by John Rodman.

1-compartment disposition with zero-order input and lag. Fraction absorbed, duration of input and lag time included as parameters. Requested by Lloyd Whitefield.

Plasma and incremental urine data (allows for missing urine measurements). Linear 1-compartment disposition, 1^st order absorption with lag, w/o IV. Contributed by Daniel Maneval.

PK model: 2 compartment disposition with IV. PD model: Hill response equation, with response at time t linked to area under the plasma concentration from 0 to t. Contributed by Alan Forrest.

PK model: 2 compartment disposition with IV. PD model: Hill response equation, with response at time t linked to the cumulative time plasma conc. is above a threshold value. Requested by Merrill Egorin.

PK model: 1 compartment disposition with IV. PD model: Indirect Response Model with endogenous production governed by a circadian rhythm and inhibited by plasma concentration. Requested by Bill Jusko.

Isolated organ disposition model with arterial drug concentration input represented as sum of exponentials. Contributed by Bill Ebling. 

Isolated organ disposition model with measured arterial concentration data represented as piece-wise linear input. Requested by Bill Ebling. 

Receptor-ligand binding kinetics. One binding site, two conformational states. Contributed by Deanna Najman. 

Kinetic model of Glutamate NMDA receptor with desensitization. Contributed by Deanna Najman, Jim-Shih Liaw, and Theodore Berger.