Biomedical Simulations Resource (BMSR)

ADAPT Pharmacokinetic/Pharmacodynamic Library Models

	DIRECT PK model: 1 compartment disposition with IV. PD model: Hill (sigmoid-Emax) response equation linked to plasma concentration.
	LINK1 PK model: 1 compartment 1^st order absorption. PDmodel: effect compartment with Hill response equation. Single dose. Following Sheiner et al.
	LINK2 PK model: 2 compartment IV and/or 1^st order absorption. PD model: effect compartment with Hill response equation. Singledose. Following Sheiner et al.
	IRMPROD1 PK model: 1 compartment disposition with IV. PD model: Indirect Response Model with production linked to plasma concentration(inhibition). Following Jusko et al.
	IRMPROD2 PK model: 1 compartment disposition with IV. PD model: Indirect Response Model with production linked to plasma concentration(stimulation). Following Jusko et al.
	IRMREM1 PK model: 1 compartment disposition with IV. PD model: Indirect Response Model with removal linked to plasma concentration (inhibition). Following Jusko et al.
	IRMREM2 PK model: 1 compartment disposition with IV. PD model: Indirect Response Model with removal linked to plasma concentration (stimulation). Following Jusko et al.
	IRMLINK PK model: 1 compartment disposition with IV. PD model: Indirect Response Model with production linked to effect concentration. Following Jusko et al.