Biomedical Simulations Resource (BMSR)

ADAPT is a computational model platform developed for pharmacokinetic and pharmacodynamic applications. It is a tool for basic and clinical research scientists involved in therapeutic drug development, designed to facilitate the discovery, exploration and application of the underlying pharmacokinetic and pharmacodynamic properties of drugs. ADAPT has been developed under the direction of David Z. D'Argenio in collaboration with Alan Schumitzky.

Two principles have guided the development of ADAPT. First, it has been designed to be general and flexible, so that only minimal restrictions are placed on the type of pharmacokinetic / pharmacodynamic models that the user can implement. Second, it incorporates numerically robust and proven algorithms to perform the program's computations. The generality of ADAPT also makes it a useful tool for dynamic system modeling applications involving sparse data systems that arise in other biomedical research areas such as cellular signal transduction, metabolism, biochemistry, toxicology, pharmacology and others.

ADAPT has been developed as part of the Service function of the Biomedical Simulations Resource (BMSR) at the University of Southern California, under support from the National Center for Research Resources and the National Institute of Biomedical Imaging and Bioengineering at the National Institutes of Health. It is distributed and supported by the BMSR at no charge to the user under the terms of a Release Agreement. We ask that all users of ADAPT provide us with a completed Release Agreement, so that we can maintain a complete data base of ADAPT users.

Features in ADAPT II Release 4

Individual Analysis Capabilities

Estimation module (ID) includes weighted least squares, maximum likelihood (ML), generalized least squares (GLS), maximum a posterior Bayesian estimation (MAP)
Simulation module (SIM) includes capabilities for single and multisubject simulations with clinicially relevant covariates
Sample schedule design module (SAMPLE) provides the ability to calculate D- and C-optimal designs

Requirements

Windows 2000/XP/Vista
        with Compaq Visual Fotran v6.x
or
Sun/Solaris
        with Sun C and Fortran

Additional Software Available
    ADAPT 5 (BETA)
        S-ADAPT