Advanced Methods of Pharmacokinetic & Pharmacodynamic Systems Analysis (1991)
by David Z. D'Argenio, Ph.D.


This volume records the proceedings of the Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource in May 1990. The meeting brought together over 120 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics, and biomedical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics.

Table of Contents
Pharmacokinetics: Physiological and Biochemical Basis
Predicting Oral Drug Absorption in Humans: A Macroscopic Mass Balance Approach for Passive and Carrier-Mediated Compounds
            D.-M. Oh, P.J. Sinko & G.L. Amidon

Pharmacokinetics of Linear Reversible Metabolic Systems
            H. Cheng & W.J. Jusko

Pharmacokinetic Models for Anticancer and Antiviral Drugs Following Administration as Novel Drug Delivery Systems
            J.M. Gallor

The Significance of Marked “Universal” Dependence of Drug Concentration on Blood Sampling Site in Pharmacokinetics and Pharmacodynamics
            W.L. Chiou

Pharmacodynamics: Measurements and Models
Physiological Alternative to the Effect Compartment Model
            N.H.G. Holford

Pharmacokinetics/Dynamics of Corticosteroids
            W.J. Jusko

Variability in Human Cardiovascular Pharmacodynamics
            D.R. Abernethy

Pharmacodynamic Modeling of Thiopental Depth of Anesthesia
            D.R. Stanski

Pharmacometrics: Modeling, Estimation and Control
Residence Time Distributions in Pharmacokinetics: Behavioral and Structural Models
            M. Weiss

Pharmacokinetic Parameter Estimation with Stochastic Dynamic Models
            D.Z. D'Argenio and R. Zhang

Relationships Between Intra- or Interindividual Variability and Biological Covariates: Application to Zidovudine Pharmacokinetics
            F. Mentré & A. Mallet

On the Single-Point, Single-Dose Problem
            G.D. Swanson

Application of Stochastic Control Theory to Optimal Design of Dosage Regimens
            A. Schumitzky

Pharmacotherapeutics: Measurement, Control and Delivery
Development of a Fiber Optic Sensor for Detection of General Anesthetics and Other Small Organic Molecules
            S. Merlo, P. Yager, & L.W. Burgess

A Bayesian Kinetic Control Strategy for Cyclosporin in Renal Transplantation
            B. Whiting, A.A. Niven, A.W. Kelman, A.H. Thomson,
            J. Anderson, A. Munday, & J.D. Briggs

Targeted Systemic Exposure for Pediatric Cancer Therapy
            J.H. Rodman & W.E. Evanst

Targeting the Effect Site with a Computer Controlled Infusion Pump
            S.L. Shafe






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