by Michael C.K. Khoo, Ph.D.
This
volume is based on the
presentations delivered at the 4th Annual Biomedical Simulations
Resource (BMSR) Short Course held in Marina Del Rey on May 21-22, 1989.
The short course was to acquaint respiratory physiologists and clinical
researchers with state-of-the-art methodologies in mathematical
modeling, experiment design and data analysis, as well as to provide an
opportunity for experimentalists to challenge modelers with their more
recent findings. This book is subdivided according to the following
four sub-themes:
- respiratory control during exercise
- empirical models and parameter estimation
- control of breathing during sleep
- neural control of respiration
Table of Contents
Part I - Modeling of Respiratory
Control During Exercise
Why and How One Models Exercise on a Computer (A Tutorial)
W.S.
Yamamoto
Analysis
of the Exercise Hyperpnea
Using Dynamic Work-Rate Forcing
R.
Casaburi
Optimal
Regulation of Ventilation
During Exercise
C.-S.
Poon
Consequences
of Lung Volume
Optimization of Exercise Hyperpnea
S.M.
Yamashiro & F.S. Grodins
Experimental
Design and Analysis for
Assessing Gas Exchange Kinetics during Exercise
G.D.
Swanson
Part II - Chemical Control of
Ventilation - Empirical Models and Parameter
Estimation
Parameter Estimation Theory for Respiratory Physiology
D.M.
Wiberg
Dynamic
End-Tidal Forcing Technique:
Modeling the Ventilatory Response to Carbon Dioxide
J.
DeGoede & A. Berkenbosch
Dynamic
Models and Parameter
Estimation: The Hypoxic Ventilatory Response
D.S.
Ward
Design
and Analysis of Experiments for
Studying Hypoxic-Hypercapnic Interactions in Respiratory Control
P.A.
Robbins
Estimation
of Dynamic Chemoreflex Gain
from Spontaneous Breathing Data
M.C.K.
Khoo
Part III - Neural Control And
Breathing Pattern Analysis
A Three-Phase Model of Respiratory Rhythm Generation
E.N.
Bruce
Conceptual
Model of Ventilatory Muscle
Recruitment and Diaphragmatic Fatigue
G.C.
Sieck
Phase
Resetting of the Respiratory
Oscillator: Experiments and Models
F.L.
Eldridge
Distinguishing
Random from Chaotic
Breathing Pattern Behavior
S.M.
Yamashiro
Forebrain
Mechanisms Related to
Respiratory Patterning During Sleep-Waking States
R.M.
Harper
Part IV - Sleep And Respiratory
Control Stability
Chemoreception in Sleep
J.A.
Dempsey, J.B. Skatrud & K.G. Henke
Potential
Causes of Recurrent Apneas
During Sleep
N.S.
Cherniack & G.S. Longobardo
Minimal
Modeling of Human Respiratory
Stability
D.W.
Carley
Sleep
State and Periodic Respiration
A.I.
Pack, A. Gottschalk, M. Cola & A. Goldszmidt
Modeling the Effect of
Sleep State on
Respiratory Stability
M.C.K.
Khoo
