Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis - Volume III (2004)

by David Z. D'Argenio, Ph.D.

Volume III records the proceedings of the 10th Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, organized by the Biomedical Simulations Resource on June 16-17, 2003. The meeting brought together over 130 investigators from a number of disciplines, including clinical pharmacology, clinical pharmacy, pharmaceutical science, biomathematics, statistics, and biomedical engineering with the purpose of providing a high-level forum to facilitate the exchange of ideas between basic and clinical research scientists, experimentalists and modelers working on problems in pharmacokinetics and pharmacodynamics. This volume is organized in three main areas: Mechanism-Based PK/PD, Pharmacometrics and Pharmacotherapy.

Table of Contents
Mechanism-Based PK/PD

Physiological Modeling of the Small Intestine in Drug Absorption
            K.S. Pang

Intracellular Metabolism of Lamivudine
            Z. Zhou, D.Z. D'Argenio, B.L. Robbins and J.H. Rodman

Mechanism-Based Pharmacodynamic Modeling for Prediction of Exposure Response
            M. Danhof, P.H. van der Graaf, S.A.G. Visser and K.P. Zuideveld

Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postreceptor Events
            M. Weiss and W. Kang

Pharmacodynamics and Pharmacogenomics of Corticosteroids: Microarray Studies
            W.J. Jusko, Jin Y. Jin, D.C. DuBois and R.R. Almon

Bayesian Inference in Physiologically-Based Pharmacokinetic Modeling: Application to Anticancer Drug Development
            L. Xu, D.Z. D'Argenio, J.L. Eiseman and M.J.Egorin

Pharmacometrics
Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/Pharmacodynamic Data
            R.J. Bauer and S. Guzy

Application of Markov Chain Monte Carlo Methods to Inverse Problems in PK/PD
            D. Kang and D. Verotta

Regenerative Markov Chain Monte Carlo Methods for Pharmacokinetic/ Pharmacodynamic Estimation
            D. Kang, A. Schumitzky and D.Z. D'Argenio

Vizstruct: A Multidimensional Visualization Algorithm for Gene Expression
            M. Ramanathan, L. Zhang and A. Zhang

Pharmacotherapy
Modeling and Simulation of Effects of Adherence, Pharmacokinetic, and Pharmacodynamic Characteristics in Development of Resistance to HIV Regimens in Treatment-Naive Patients
            A. Hsu, R. Wada, B. Poland, E. Sun and R.G. Granneman

Mechanistic PK/PD Modeling of Antiretroviral Therapies in AIDS Clinical Trials
            Y. Huang and H. Wu

Dose Individualization for High-Dose Anti-Cancer Chemotherapy
            G.L. Rosner, P. Müller, F. Tang, T. Madden and B.S. Andersson

Toward Model-Based Chemotherapy Treatment Design
            R.S. Parker, J.M. Harrold, J.L. Eiseman, W.C. Zamboni, E. Joseph, S. Strychor and M.J. Egorin

Control of Uncertain Pharmacodynamic Systems
            K. Park and D.Z. D'Argenio





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