Core Research
The
emphasis of the Core Research
projects is on the development of advanced modeling and simulation
methodologies and their application to physiological systems for the
advancement of scientific knowledge and improvement of clinical
practice. The challenging cases of nonlinear, nonstationary, sparse
data and feedback systems, as well as the issues of physiological
control, neural information processing, learning and memory,
pharmacokinetics and pharmacodynamics, and modeling/simulation of
complex biomedical systems constitute the focal points of this effort.
The methodologies explored and developed by the Core projects are at
the cutting edge of research in each area. Together they comprise a
research ensemble of common origin and coherent scope, yet pluralistic
in methodological approach and application focus. Pivotal applications
of these methodologies cover a variety of physiological domains,
including pharmacokinetics, respiratory, cardiovascular, neural,
sensory and motor systems.
Core Investigators
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Core
Project #1 Nonlinear and Nonstationary Modeling of Biomedical Systems Vasilis Z. Marmarelis, Ph.D. Co-Director, BMSR Professor, Biomedical and Eletrical Engineering |
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Core
Project #2 Pharmacokinetic/Pharmacodynamic Systems Analysis David Z. D'Argenio, Ph.D. Co-Director, BMSR Professor, Biomedical Engineering Chonette Chair in Biomedical Technology |
 |
Core
Project #3
Dynamic Modeling of State-Cardiorespiratory Interactions Michael C.K. Khoo, Ph.D. Co-Investigator, BMSR Professor, Biomedical Engineering Dwight C. Hildagarde E. Baum Chairman of Biomedical Engineering |
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Core
Project #4 Nonlinear Model of the Hippocampus Theodore W. Berger, Ph.D. Co-Investigator, BMSR Professor, Biomedical Engineering and Neurobiology David Packard Chair of Engineering |
