Archive for 2015

Support for Intel Visual Fortran Compiler 2016

ADAPT (version 5.0.052). The installation was updated to conform to Intel® Intel Visual Fortran Compiler 2016 for Windows on both 32 and 64bit processors. See Installation Tab file on the ADAPT download page for full details. Also updated: the Validation program to fix a bug that caused Validate to fail on some Windows 7 and 8 systems; SIM, so that parameters values are not displayed on first run, and a *DAT.dat file automatically created.

Multi-scale Modeling of PK, Intracellular Signaling and Tumor Burden

A recent publication in the Journal of PK/PD presents a model-based analysis of the relative contributions of FLT3ITD and CDK4/6 inhibition on downstream signaling and tumor burden in acute myeloid leukemia. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia Yaping Zhang, Cheng-Pang Hsu, Jian-Feng Lu, Mita Kuchimanchi, Yu-Nien Sun, Ji Ma, Guifen Xu, Yilong Zhang, Yang Xu, Margaret Weidner, Justin Huard, David Z. D’Argenio, Journal of Pharmacokinetics and Pharmacodynamics. 41(6) :675-692, 2014 [PMC4226810] FLT3ITD subtype acute myeloid leukemia (AML) has a poor prognosis with currently available therapies. A number of small molecule inhibitors of FLT3 and/or CDK4/6 are currently under development. A more complete and quantitative understanding of the mechanisms of actions of FLT3 and CDK4/6 inhibitors may better inform the development of current and future compounds that act on one or both of the molecular targets, and thus may… Read more

Address problem with Microsoft Visual Studio Distributed with Intel Fortran Compiler

Includes an updated patch to address a problem with the Microsoft Visual Studio Linker distributed with Intel Fortran that prevented proper installation of ADAPT on some Windows 7 systems.

Support for Intel Fortran Composer XE 2015 Update 1

ADAPT (version 5.0.050): The installation was updated to conform to Intel® Parallel Studio XE 2015 Update 1 Composer Edition for Fortran Windows (Intel’s current version of its Fortran Compiler) on both 32 and 64bit processors. It also corrects a problem with the Microsoft Visual Studio Linker distributed with Intel Fortran, which resulted from an update to Windows.